冬蟲夏草固體發(fā)酵物水提液抗疲勞作用初步研究Anti-fatigue Activity of Hot Aqueous Extracts of Ophiocordyceps sinensis Mycelium Evaluated Using a Mouse Model

【作者】 閆文娟； 李泰輝； 勞景輝； 沈亞恒； 方佳茂；

【Author】 YAN Wenjuan1,LI Taihui1,LAO Jinghui1,SHEN Yaheng 1,FANG Jiamao2(1Guangdong Institute of Microbiology,Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,Guangdong Open Laboratory of Applied Microbiology,State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base),South China,Guangzhou,Guangdong 510070,China;2Huanxi Biological Technology Co.,Ltd,Puning,Guangdong 515343,China)

【機(jī)構(gòu)】 廣東省微生物研究所,廣東省菌種保藏與應(yīng)用重點(diǎn)實(shí)驗(yàn)室,廣東省微生物應(yīng)用新技術(shù)公共實(shí)驗(yàn)室,廣東省華南應(yīng)用微生物重點(diǎn)實(shí)驗(yàn)室—省部共建國家重點(diǎn)實(shí)驗(yàn)室培育基地； 廣東環(huán)西生物科技股份有限公司；

【摘要】 通過研究冬蟲夏草(Ophiocordyceps sinensis)固體發(fā)酵物水提液對負(fù)重小鼠游泳時(shí)間的影響,初步探討其抗疲勞作用。結(jié)果表明:與陰性對照組相比,灌胃喂養(yǎng)冬蟲夏草固體發(fā)酵物水提液的小鼠負(fù)重游泳時(shí)間顯著延長,證明在本試驗(yàn)條件下冬蟲夏草固體發(fā)酵物具有顯著的抗疲勞作用。

【Abstract】 Ophiocordyceps sinensis mycelium was grown in 250 mL glass bottles on a solid medium consisting of 1% glucose,0.5% peptone,0.3% yeast extract and 0.3% malt extract in distilled water mixed with rice(1.5∶1).Hot(80-99 ℃) aqueous extracts of fungal mycelium grown for 25-30 d were administered to mice as part of their daily liquid intake(0.2 mL/10 g body weight) for 30 d and the anti-fatigue effects were evaluated using the weight-loaded swimming times of the mice as indicator.Extracts at a dose lev...

【關(guān)鍵詞】 冬蟲夏草； 小鼠； 抗疲勞；

【Key words】 Ophiocordyceps sinensis； hot aqueous extracts； anti-fatigue effects in mice；

【基金】 廣東省基金項(xiàng)目(編號:10151007002000006);廣東省科技計(jì)劃項(xiàng)目(編號:2009B080702029、2010A030100015);廣東省產(chǎn)學(xué)研項(xiàng)目(編號:2011B090400625)的部分研究內(nèi)容

【分類號】R285.5