【作者】 肖春； 吳清平； 蔡玟； 譚劍斌； 黃俊明； 楊小兵；

【Author】 XIAO Chun1,2,4,WU Qing-ping2,CAI Wen3,TAN Jian-bin3,HUANG Jun-ming3,YANG Xiao-bing2 (1.South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou Guangdong 510301;2.Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,Guangdong Institute of Microbiology,Guangzhou Guangdong 510070;3.Department of Toxicology of the Center for Disease Control and Prevention of Guangdong Province,Guangzhou Guangdong 510020;4.Graduate School of the Chinese Academy of Sciences,Beijing 100049)

【機(jī)構(gòu)】 中國(guó)科學(xué)院南海海洋研究所； 廣東省微生物研究所廣東省菌種保藏與應(yīng)用重點(diǎn)實(shí)驗(yàn)室； 中國(guó)科學(xué)院研究生院； 廣東省疾病預(yù)防控制中心；

【摘要】 研究靈芝粗多糖對(duì)糖尿病小鼠的降血糖作用。灌胃5周后,劑量組與糖尿病模型對(duì)照組的血糖,有顯著性差異(p<0.01),高劑量組與低劑量組的血糖水平,組間差異顯著(p<0.01);劑量組小鼠的血清胰島素值與糖尿病模型對(duì)照組比較,顯著降低。靈芝粗多糖能顯著降低糖尿病小鼠的空腹血糖,并呈現(xiàn)一定的劑量依賴(lài)關(guān)系,但其降血糖機(jī)理不是刺激胰島素的分泌。

【Abstract】 The hypoglycemic effect of Ganoderma lucidum crude polysaccharides(GLP) in type 2 diabetes mellitus(DM) mice and hypoglycemic mechanism were investigated.The results showed that after five weeks,there existed a significant difference(p<0.01) in serum glucose between the test groups and the model control group,as well as between the high and the low-dose groups.However,GLP had no obvious effect on serum insulin.GLP was able to significantly decrease fasting blood glucose level in DM mice in ce...

【關(guān)鍵詞】 靈芝粗多糖； 降血糖活性； 糖尿病；

【Key words】 Ganoderma lucidum crude polysaccharides； Hypoglycemic activity； Diabetes mellitus mice；

【基金】 廣東省科技計(jì)劃項(xiàng)目(項(xiàng)目編號(hào):2008A020100024、2009GB2E000279)

【分類(lèi)號(hào)】R285